PARIS (AFP) – A new treatment for obesity that combines two existing drugs resulted in twice as much weight loss as the only approved long-term anti-obesity medication, according to a study released Monday.
A mix of Phentermine and topiramate, sold under the brand name of Topamax, was shown in clinical trials to be twice as effective as orlistat, which is commercialised in some countries as Xenical or Alli, it said.
The drug combo appears to have additional health benefits, including improved "markers," or indicators, for blood pressure, sugar levels, lipids and inflammation, it added.
Phentermine is the most widely prescribed short-term weight drug in the United States.
Topiramate is an anticonvulsant approved for treating seizure disorders and migraines. It has been shown to work well for weight loss in obese patients with type 2 diabetes, but -- taken alone -- has also been linked to cognitive and psychiatric side effects.
Lower doses taken with a controlled-release mechanism and in combination with other drugs would likely reduce those side effects, tests have shown.
Led by Kishore Cadde of the Duke University Medical Centre, in Durham, North Carolina, the new trial was conducted over 20 months with nearly 2,500 overweight or obese adults with at least two major health-risk symptoms.
The patients were divided into three groups.
One was given a once-a-day dose of 7.5 mg of Phentermine and 46 mg of topiramate, while a second group was given 15 and 92 mg of the same drugs, respectively.
The third group were given look-alike placebos.
After 56 weeks of treatment, the low-dose group dropped, on average, 8.1 kilos (18 pounds) while the high-dose group shed 10.2 kilos (22 pounds).
Patients given placebos lost 1.4 kilos (3.0 pounds).
Overall, 62 percent of the low-dose patients lost at least five percent of body weight, while 70 percent in the high-dose cohort crossed the same threshold.
Patients given placebos lost 1.4 kilos (3.0 pounds), with 21 percent sloughing five percent off their total weight.
The two-drug treatment was well tolerated physically, with only sporadic cases of dry mouth and constipation, according to the study, which is published by The Lancet.
The high-dose group, however, showed a higher dropout rate due to adverse cognitive and psychiatric reactions.
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Weight Watchers says eat at McDonald's to lose weight (opinion)
Weight Watchers has now officially endorsed Chicken McNuggets as a "healthy meal" in New Zealand, where McDonald's restaurants will begin carrying the Weight Watchers logo on several menu items. This bizarre and inexplicable decision has now made Weight Watchers the laughing stock of the health world where nutrition and weight loss experts normally don't use "McDonald's fast food" and "weight loss" in the same sentence.
As The Guardian reports, "As part of the deal, which the company says is the first of its kind in the world, McDonald's will use the Weight Watchers logo on its menu boards and Weight Watchers will promote McDonald's to dieters."
Nutritionists, not surprisingly, were shocked at the announcement. The idea of eating at McDonald's to lose weight seems a bit ridiculous, and anyone who believes that eating Chicken McNuggets will cause you to lose weight is arguably one nugget short of a Happy Meal. Sometimes you just have to point out the stupidity of these things, even at the risk of offending someone who has convinced themselves that eating more Chicken McNuggets is their ticket to a slim, fit and sexy body.
A new study has stated that weight loss can be triggered even more if along with formal counseling on lifestyle changes, an experimental obesity drug is taken.
About 800 adults were enrolled for the study of a drug called Contrave. Contrave is made by combining the antidepressant bupropion (Wellbutrin) and naltrexone.
It has been seen in trials that Contrave generally has outperformed other placebo pills when it comes to weight loss.
Over a year it was seen that the study participants taking Contrave last about six per cent of their initial weight as compared to those who took placebos.
If the medication is combined with diet counseling and a little changes are made in the lifestyle then weight loss can be achieved.
Contrave was found to be more effective in weight loss when participants in the drug-plus-counseling group lost 9 per cent of their initial weight, which was much more than those who took placebos.
According to research, visiting a Website that is interactive can actually help you shed those extra pounds.
Lead researcher Kristine L. Funk of the Kaiser Permanente Center for Health Research in Portland, Oregon, said that people lost more weight by using a web-based records keeping resource for about two-and-a-half-years at least once a month as compared to people who did not visit such Websites.
About 348 people were followed for making observations for the study and these were those people who lost weight using Web-based method. They were able to keep off about five pounds after logging once a month.
Funk said, "Consistency and accountability are essential in any weight maintenance program. The unique part of this intervention was that it was available on the Internet, whenever and wherever people wanted to use it."
Co-author Dr. Victor J. Stevens added that it was more difficult to keep the lost weight from coming back when compared to just losing weight. In the study people were able to keep their weight off and this is really good.
Yoga may not conjure up the same images of a calorie-burning, sweat-inducing workout as, say, Buns of Steel or Tae Bo.
But don’t be fooled by yoga’s deep breathing and sometimes-slow poses: Doctors and personal training experts say it can seriously trim and tone your body — and also work on your mind and spirit to help you get healthier overall.
So take in what experts say about how to do yoga for weight loss, and get ready to pare down with some downward dogs.
Go beyond the burn
Calories burned during yoga vary widely — from 180 to 360 per hour — depending on the type of yoga you practice. Fitness director Guy Caracciolo at the Dedham Health and Athletic Complex in Dedham, Mass., places Vinyasa, Ashtanga and other forms of “power yoga” at the top, along with yoga fusion workouts that accelerate calorie burning by mixing it up with dance or kickboxing.
Big Apple Power Yoga owner Nanci Muriello in New York City agrees, recommending power yoga for its weight-loss triple force: strength, flexibility and cardio. During a typical 90-minute session, the deep breathing techniques heat you up inside, helping to flush out toxins and water weight and boost performance of the lymphatic system and organs. “It’s a great physical workout,” Muriello says.
But as with all styles of yoga, there’s a deeper benefit: You’re tuning in to your body.
“Suddenly you actually get the signal that you are full or that a particular food doesn’t digest well, or you notice after you eat something that you feel amazing,” says Muriello.
Sometimes, less is more
“It’s not necessarily the hardcore class that’s going to help,” says Oakland, Calif., physician Baxter Bell, M.D., who’s also a yoga instructor and medical acupuncturist.
Ironically, gentle and restorative yoga can help with weight loss, Bell says — by kicking on the parasympathetic nervous system, which regulates breathing, digestion and hormones.
As you jet through the day in fifth gear, your body is often in fight-or-flight mode, and high-octane hormones are circulating. By activating the parasympathetic nervous system, you’re stepping (gently) on your internal brakes, which lets everything take a rest: Hormones rebalance, injuries begin repairing, and digestion proceeds normally — all of which can aid weight loss, Bell says.
Gentle yoga is also a good way to start slowly, which is crucial if you’re new to yoga to avoid injuries that could immobilize you and blow all hopes for weight loss at least for a while — and serving as a enough of a buzzkill that you write off yoga altogether.
Strike a (fat-burning) pose
Certain poses, or asanas, are “killer apps” for weight loss, with “benefits that far exceed mere calorie burning and muscle strengthening,” says Nicole Persley, a teacher at Yoga and Inner Peace in Lake Worth, Fla. “Yoga speeds up the metabolism by stimulating endocrine glands that regulate the metabolic rate,” she explains.
Certain poses can also help with trouble spots. Persley suggests the following:
* Shoulder stand and fish pose: Both rouse the thyroid, helping to boost your body’s metabolism.
* Valrasana (spinal twist), a lengthening child’s pose, and cobra pose: These twisting poses massage the abdomen, target internal organs and aid with optimal digestion.
* The dogs: Downward-facing dog and upward-facing dog poses are particularly helpful in toning hips and thighs.
Ask your doctor before you begin, and then go to a class, get a yoga DVD or get other how-to on basic yoga positions.
But while you’re striking poses — particularly in fast-moving vinyasa or power yoga — it’s crucial that you pay attention to your body, says fitness instructor Patricia Moreno, founder of intenSati and creator of several yoga-fusion and weight loss DVDs for Gaiam.
“Good alignment is always important but when people are too focused on burning calories they sometimes compromise alignment,” says Moreno.
Broaden your goals
Think big picture — considering not only your physical body, but also your spirit. “Ask yourself, ‘Why do I want to lose weight?’” Bell suggests. Is it for self-image, a relationship, to boost energy?
Whatever it is, devise some related goal such as reaching a career milestone or being able to take the stairs or play with your kids without getting out of breath. Then notice your total successes as you move forward, Bell suggests. If, say, your goal was better health and your breathing has improved and your lower back has strengthened due to yoga — even if you haven’t yet lost a lot of pounds — give yourself some credit and keep up the good work.
Expect long-term results
Research shows that yoga can help stop middle-age spread. Overweight folks who regularly practiced yoga for 10 years between ages 45 and 55 lost five pounds on average, compared to a 14-pound gain for those who didn’t, according to a 2005 study from Seattle’s Fred Hutchinson Cancer Research Center.
“From my experience, it has to do with the way that yoga makes you more aware of your body,” says Alan Kristal, Ph.D., lead author of the study.
Yoga practioners also simply ate more mindfully — and had a lower body mass index – than non-practioners, explains Kristal. In other words, they notice when they’re full, and more easily avoid eating out of stress or boredom.
“Yoga teaches awareness of the self, which is important for long-term change,” Moreno points out. “Use this higher level of awareness to help you make healthier eating choices and decrease mindless eating.”
When I take my daughter to her dance class at our community rec center, I’m always amazed at the number of people pacing doggedly on the treadmill or working up a sweat in spinning class — even when it’s sunny and 70 degrees outside.
“This is Boulder, Colorado!” I think to myself. “We have acres and acres of public Open Space, miles and miles of running and cycling paths and hiking trails. Why would anyone choose to exercise indoors?”
The answer likely lies in a concept that’s at the core of getting — and staying — in shape: fitness personality.
I thrive on nature and novelty. The thought of a regular gym workout under fluorescent lights bores me before I even try it. But someone else may be inspired by the predictable routine and location I loathe. Ensuring that your fitness regimen jives with your fitness personality is the key to making exercise easier and more enjoyable — and thus a more consistent part of your life.
If you poll your friends about their exercise habits, patterns will start to emerge. My friend Mimi is out the door for a walk at 5:30 a.m. without fail, even in the dark and cold of winter. My sister-in-law spends her early mornings on her home treadmill. As for me, I can barely rouse myself before the sky is light, and the only thing that guarantees any discipline is if I have shelled out money for a gym class. Ideally, it’s a dance class, with invigorating music. We clearly have different fitness personalities!
Why should you identify your fitness personality?
“Fitness personality” is a concept that’s gained traction among exercise experts. Jonathan Niednagel, an athletic consultant for professional teams and author of Your Key to Sports Success, explains how understanding your inborn brain type can help motivate you, choose which sport and speed you’re best suited for, and which athletic pursuits to avoid. In Suzanne Brue's book The 8 Colors of Fitness, she applies principles from the popular Myers-Briggs personality inventory to help readers develop a personalized exercise program within eight color-coded types. And Susan Davis-Ali, Ph.D., who has developed a Fitness Interest Profile survey for the Life Time Fitness health club chain, says research suggests that people who engage in activities appropriate for their personalities will enjoy their workouts more and are likely to stay with them longer.
By identifying your fitness personality, you can create an exercise program that suits your rhythms and interests, which comprise who you are. Working with your personality, rather than against it, can help you find a fitness approach that can become an integral part of your life.
Maybe getting fit is a brand-new goal for you. Consider your overall orientation to life and relationships — do you like consistency or change? Time alone to think or lots of conversation with friends? Are you geared toward goals, or do you prefer to relax and see what unfolds? Do you like to get up early and get your obligations out of the way, or are you more spontaneous, tackling tasks as the spirit moves you during the day?
Based on a range of composites from the growing literature on fitness personalities, we’ve put together some categories to help you assess yours. Find one that captures the way you feel about exercise — there may be several. Then, check out the recommended workout possibilities, and get moving in a manner that works for you, not against you!
