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Varenicline may raise CV events in CVD patients: FDA

Posted by weigthloss-diets Friday, August 5, 2011 6 comments

The smoking-cessation drug varenicline (Chantix, Pfizer) may be associated with a small increased risk of cardiovascular events in patients with cardiovascular disease, according to the Food and Drug Administration (FDA) [1].

The new safety communication, which will be added to the warnings and precautions section of the drug's label, states that physicians need to balance the known benefits of varenicline—a drug effective in helping patients quit smoking—with the potential risks when deciding to use the drug in patients with cardiovascular disease.

In a review of a randomized, double-blind, placebo-controlled study of 700 patients treated with varenicline for smoking cessation, there was an increased risk of nonfatal MI, revascularization, angina pectoris, and peripheral vascular disease when compared with patients treated with placebo. Although the study was not designed to detect a statistical difference in the clinical end points, cardiovascular events were numerically higher among the 353 patients treated with varenicline.

The FDA states that physicians should speak with patients about seeking medical attention if they experience new or worsening symptoms of cardiovascular disease while taking varenicline.

In July 2009, the FDA required a new boxed warning for varenicline, stating that the drug has been associated with serious mental-health events. Reported symptoms include changes in behavior, hostility, agitation, depressed mood, suicide ideation, and attempted suicide.

Varenicline, an oral nicotine-receptor blocker, was approved by the FDA in May 2006 under the agency's priority-review program.

Two-drug obesity treatment effective: study

Posted by weigthloss-diets Monday, April 11, 2011 5 comments

PARIS (AFP) – A new treatment for obesity that combines two existing drugs resulted in twice as much weight loss as the only approved long-term anti-obesity medication, according to a study released Monday.

A mix of Phentermine and topiramate, sold under the brand name of Topamax, was shown in clinical trials to be twice as effective as orlistat, which is commercialised in some countries as Xenical or Alli, it said.

The drug combo appears to have additional health benefits, including improved "markers," or indicators, for blood pressure, sugar levels, lipids and inflammation, it added.

Phentermine is the most widely prescribed short-term weight drug in the United States.

Topiramate is an anticonvulsant approved for treating seizure disorders and migraines. It has been shown to work well for weight loss in obese patients with type 2 diabetes, but -- taken alone -- has also been linked to cognitive and psychiatric side effects.

Lower doses taken with a controlled-release mechanism and in combination with other drugs would likely reduce those side effects, tests have shown.

Led by Kishore Cadde of the Duke University Medical Centre, in Durham, North Carolina, the new trial was conducted over 20 months with nearly 2,500 overweight or obese adults with at least two major health-risk symptoms.

The patients were divided into three groups.

One was given a once-a-day dose of 7.5 mg of Phentermine and 46 mg of topiramate, while a second group was given 15 and 92 mg of the same drugs, respectively.

The third group were given look-alike placebos.

After 56 weeks of treatment, the low-dose group dropped, on average, 8.1 kilos (18 pounds) while the high-dose group shed 10.2 kilos (22 pounds).

Patients given placebos lost 1.4 kilos (3.0 pounds).

Overall, 62 percent of the low-dose patients lost at least five percent of body weight, while 70 percent in the high-dose cohort crossed the same threshold.

Patients given placebos lost 1.4 kilos (3.0 pounds), with 21 percent sloughing five percent off their total weight.

The two-drug treatment was well tolerated physically, with only sporadic cases of dry mouth and constipation, according to the study, which is published by The Lancet.

The high-dose group, however, showed a higher dropout rate due to adverse cognitive and psychiatric reactions.

Lose Weight with Every Other Day Diet

Posted by weigthloss-diets Friday, March 4, 2011 2 comments

Obesity is a threat to mankind. It reduces the average life of a human being Every Other Day Diet. Apart from that it invites lots of petty to major health issues. And of course it makes you look all unattractive and you shy away from public. Hence takes a toll on your self confidence as well. So getting rid of this excess weight becomes a necessity for the over all well being.

This Every Other Day Diet plan makes use of the calories cycling method to help you loose weight. The basic mechanism of the diet is that you are allowed to eat all your favorite foods on alternate days. The diet is extremely easy to understand. Most of the diets you must have come across will ask you to give up your favorite food and you’ll feel deprived. This deprivation is the sole reason as to why you can’t stick to them for long. The Every Other Day Diets that Work comes in three levels and based on that you get to choose the pace at which you want to loose weight. That makes the diet extremely flexible and you can customize it according to your need.

The Every Other Day Diet makes your weight loss goals very clear and practical. You are not promised a miracle weight loss. You need to stick to the diet diligently to be able to see results. The fact that you are no longer craving for the food that you love is deterring you from binging and hence gaining back the lost weight. If you are tired with the yo-yo diets and want to try something that actually helps; try the Every Other Day Diet. You get a 100% money back guarantee and great bonuses along with the sign up. It’s a risk free venture and all you end up loosing is your excess weight.

Weight Watchers says eat at McDonald's to lose weight (opinion)

Posted by weigthloss-diets Thursday, February 10, 2011 0 comments

Weight Watchers has now officially endorsed Chicken McNuggets as a "healthy meal" in New Zealand, where McDonald's restaurants will begin carrying the Weight Watchers logo on several menu items. This bizarre and inexplicable decision has now made Weight Watchers the laughing stock of the health world where nutrition and weight loss experts normally don't use "McDonald's fast food" and "weight loss" in the same sentence.

As The Guardian reports, "As part of the deal, which the company says is the first of its kind in the world, McDonald's will use the Weight Watchers logo on its menu boards and Weight Watchers will promote McDonald's to dieters."

Nutritionists, not surprisingly, were shocked at the announcement. The idea of eating at McDonald's to lose weight seems a bit ridiculous, and anyone who believes that eating Chicken McNuggets will cause you to lose weight is arguably one nugget short of a Happy Meal. Sometimes you just have to point out the stupidity of these things, even at the risk of offending someone who has convinced themselves that eating more Chicken McNuggets is their ticket to a slim, fit and sexy body.

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